INFLUENCE OF INTRAPERITONEAL ADMINISTRATION OF CERIUM OXIDE ON BLOOD PARAMETERS AND LIPID PROFILE IN MICE (MUS MUSCULUS)
DOI:
https://doi.org/10.47604/ijb.1221Keywords:
Cerium oxide, liver enzymes, Kidney, ratsAbstract
Purpose: White laboratory mice Mus musculus L. strain BALB / C were used to study the effects cerium oxide on the hematological parameters and lipid profile values.
Results: Results showed a significant decrease (p≤0.05) in the RBCs' hemoglobin Hb 'and PCV' parameters as well as the presence of a significant in the mean erythrocyte MCV volume in the two doses (2.5'and .3.75) micro liters / kg ' , while there was no significant difference in hemoglobin (MCH) and the mean concentration of hemoglobin in red blood cells (MCHC) when compared with the control group, while the two doses did not differ significantly in PCV, Hb, RBCs, while the two doses differed significantly between them in MCV. There is significant difference in the level of triglycerides (TG, LDL) and HDL (compared with the control group) for both doses, and it was found that there was a significant difference between the low and high dose (2.'3.75) micro liters / kg in the HDL level. TG, LDL) compared with the control group at the probability level (P≤0.05), while there was no difference between the high and low dose in the level of cholesterol and (VLDL).
Downloads
References
(1) Ju-Nam, and J. R. Lead. Manufactured nanoparticles: An overview of their chemistry, interactions and potential environmental implications. The Science of the Total Environment .2008-400 (1-3) 396-414
(2) Gaiser B. ,, Teresa F Fernandes, Mark A Jepson, Jamie R Lead, Charles R Tyler, Mohammed Baalousha, Anamika Biswas, Graham J Britton, Paula A Cole, Blair D Johnston, Yon Ju-Nam, Philipp Rosenkranz, Tessa M Scown, Vicki Stone . Interspecies comparisons on the uptake and toxicity of silver and cerium dioxide nanoparticles. Environ Toxicol Chem.2012) ;31(1):144-54
(3) Xia D, et al,. Structural analysis of cytochrome bc1 complexes: implications to the mechanism of function. Biochim Biophys Acta .2013)1827(11-12):1278-94.
(4)Shaw P., Sharp W, Jonathan B. Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. National Academy of Sciences.2007- 104(49):19649-54
(5) Jessica T. Dahle and Yuji Arai .Environmental Geochemistry of Cerium: Applications and Toxicology of Cerium Oxide Nanoparticles. IJERPH 2015-Volume 12 Issue 2 10.3390
(6) Dreher A.(2004)The Influence of IMF Programs on the Re"election of Debtor Governments.Economic and politics Volume16, Issue1Pages 53-76.
(7) Park, J., Park, S., Seryun Kim, S., Jaeyoung C., Ahn, J., Seungmin L., Sunggon K. An informatics pipeline supporting phylogenomic analysis of fungal transcription factors .Bioinformatics,2008- Volume 24, Issue 7, , Pages 1024-1025,
(8)Reeda, C Daniel , Christopher K. Algarb , Julie A. Huberb , and Gregory J. Dicka Gene-centric approach to integrating .environmental genomics and biogeochemical models .February 4, 2014 . vol. 111 . no. 5 : 1879-1884
(9)Adua OA and Akinmuyisitana IW (2013) Growth performance and blood profile of female rabbits fed dietary Cerium Oxide .Journal of Bio-Science. Vol 21 .
(10)Massod Negahdary, A Asadi, S Mehrtashfar, M Imandar, H Akbari-Dastjerdi A biosensor for determination of H2O2 by use of HRP enzyme and modified CPE with ZnO NPsInternational .Journal of Electrochemical Science.2012- 7 (6), 5185-5194
(11)Ali Alkaladi a,d , Nasr A.M. Nasr El-Deen b , Mohamed Afifi a,c,d , Osama A. Abu Zinadah a, (2015) Hematological and biochemical investigations on the effect of vitamin E and C on Oreochromis niloticus exposed to zinc oxide nanoparticles Saudi Journal of Biological SciencesVolume 22, Issue 5, Pages 556-563
(12) Neda Eskandari, , Sanaz Nikpur,2 Ghazal Ghasrahmad, Farnoosh Attar,et al.,(2018)Biophysical, docking, and cellular studies on the effects of cerium oxide nanoparticles on blood components: in vitro. Int J Nanomedicine. 2018; 13: 4575-4589
(13)Winfried März, Marcus E. Kleber, Hubert Scharnagl, Timotheus Speer, Stephen Zewinger, Andreas Ritsch, Klaus G. Parhofer, Arnold von Eckardstein, Ulf Landmesser, and Ulrich Laufs (2017)HDL cholesterol:reappraisal of its clinical relevance. Clin Res Cardiol. 2017; 106(9): 663-675.
(14)Fumiaki Ito and Tomoyuki Ito .High-Density Lipoprotein (HDL) Triglyceride and Oxidized HDL: New Lipid Biomarkers of Lipoprotein-Related Atherosclerotic Cardiovascular Disease. Antioxidants (Basel).;2020- 9(5): 362.
(15)Nazila Pourkhalili, Asieh Hosseini, Amir Nili-Ahmadabadi, Shokoufeh Hassani, Mohsen Pakzad, Maryam Baeeri, Azadeh Mohammadirad, and Mohammad Abdollahi(2011(Biochemical and cellular evidence of the benefit of a combination of cerium oxide nanoparticles and selenium to diabetic rats. World J Diabetes 15; 2(11): 204-210.
(16)Silvia Carvajal , Meritxell Perramón , Denise Oró , Eudald Casals , Guillermo Fernández-Varo , Gregori Casals , Marina Parra , Bernardino González de la Presa , Jordi Ribera , Óscar Pastor , Manuel Morales-RuÃz , VÃctor Puntes , Wladimiro Jimnez (2019)Cerium oxide nanoparticles display antilipogenic effect in rats with non-alcoholic fatty liver disease. Sci Rep. 6;9(1):12848
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Samaher Sabri Hammid , Sami Jeber Al-Maliky
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution (CC-BY) 4.0 License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
