Favourable Clinical and Functional Outcomes Following Total Knee Replacement Surgery in a Kenyan Hospital: A 6-Week Follow-Up Study
DOI:
https://doi.org/10.47604/jhmn.3182Keywords:
Total Knee ReplacementAbstract
Purpose: The incidence of total knee replacement (TKR) is increasing due to factors such as heightened patient satisfaction, an ageing population, and the obesity epidemic, all of which lead to more significant stress on weight-bearing joints. This study determined the incidence of prosthetic knee joint infection, evaluated functional recovery, and analysed rehabilitation progress among orthopaedic patients who underwent Total Knee Replacement in a hospital in Kenya.
Methodology: This study employed a prospective cohort study design for six months, following 75 patients who had undergone TKR at Metropolitan Hospital in Nairobi County. Data collection methods included medical record reviews, patient interviews, and clinical assessments. Specifically, standardized questionnaires and assessment tools were utilized, including the short form health survey (SF-12) for quality-of-life assessment, the visual analogue scale (VAS) for pain measurement, and relevant scales for activities of daily living (ADL) assessment. The incidence density of prosthetic joint infection was calculated using the conventional formula, accounting for new cases and patient time at risk. We observed that functional outcomes post-TKR are generally favourable, with patients who were followed up resuming their daily activities in a relatively short timeframe of less than six weeks.
Findings: By the sixth week, 60% of the patients had undergone excellent rehabilitation progress. The incidence of prosthetic knee infection was notably low (9 cases per 1000 patient weeks) and was only associated with age, perhaps highlighting the effectiveness of the applied surgical techniques and postoperative care. Additionally, we identified that comorbid conditions, particularly diabetes and hypertension, are the primary factors that contributed to delayed healing and resumption of daily activities following TKR.
Unique Contribution to Theory, Practice and Policy: Favourable outcomes and low infection rates indicate that total knee replacement (TKR) is a safe and effective option for patients with severe knee pain, significantly improving quality of life and mobility. However, the association between age and infection risk necessitates thorough preoperative assessments and age-specific care protocols, especially for older patients. Additionally, comorbidities like diabetes and hypertension can delay healing, highlighting the need for targeted preoperative interventions. Optimizing the management of these conditions may enhance recovery and reduce complications. Further research is essential to explore how these comorbidities affect healing post-TKR and to assess the effectiveness of specific interventions.
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Ahmed, A. A., Mooar, P. A., Kleiner, M., Torg, J. S., & Miyamoto, C. T. (2011). Hypertensive patients show delayed wound healing following total hip arthroplasty. PLoS ONE, 6(8). https://doi.org/10.1371/journal.pone.0023224
Bade, M. J., Kohrt, W. M., & Stevens-Lapsley, J. E. (2010). Outcomes before and after total knee arthroplasty compared to healthy adults. Journal of Orthopaedic and Sports Physical Therapy, 40(9), 559–567. https://doi.org/10.2519/jospt.2010.3317
Belmont, P. J., Goodman, G. P., Waterman, B. R., Bader, J. O., & Schoenfeld, A. J. (2014). Thirty-day postoperative complications and mortality following total knee arthroplasty : Incidence and risk factors among a national sample of 15,321 patients. In Journal of Bone and Joint Surgery (Vol. 96, Issue 1, pp. 20–26). Journal of Bone and Joint Surgery Inc. https://doi.org/10.2106/JBJS.M.00018
Bonasia, D. E., Palazzolo, A., Cottino, U., Saccia, F., Mazzola, C., Rosso, F., & Rossi, R. (2019). Modifiable and nonmodifiable predictive factors associated with the outcomes of total knee arthroplasty. Joints, 7(1), 13–18. https://doi.org/10.1055/s-0039-1678563
Caprari, E., Porsius, J. T., D’Olivo, P., Bloem, R., Vehmeijer, S. B. W., Stolkc, N., & Melles, M. (2018). Dynamics of an orthopaedic team: Insights to improve teamwork through a design thinking approach. Work, 61(1), 21–39. https://doi.org/10.3233/WOR-182777
Christensen, J. C., Paxton, R. J., Baym, C., Forster, J. E., Dayton, M. R., Hogan, C. A., & Stevens-Lapsley, J. E. (2020). Benefits of direct patient discharge to outpatient physical therapy after total knee arthroplasty. Disability and Rehabilitation, 42(5), 660–666. https://doi.org/10.1080/09638288.2018.1505968
Delaie, C., Cerlier, A., Argenson, J. N., Escudier, J. C., Khakha, R., Flecher, X., Jacquet, C., & Ollivier, M. (2023). Ecological Burden of Modern Surgery: An Analysis of Total Knee Replacement’s Life Cycle. Arthroplasty Today, 23. https://doi.org/10.1016/j.artd.2023.101187
Ditton, E., Johnson, S., Hodyl, N., Flynn, T., Pollack, M., Ribbons, K., Walker, F. R., & Nilsson, M. (2020). Improving patient outcomes following total knee arthroplasty: Identifying rehabilitation pathways based on modifiable psychological risk and resilience factors. Frontiers in Psychology, 11. https://doi.org/10.3389/fpsyg.2020.01061
Edwards, R. R., Campbell, C., Schreiber, K. L., Meints, S., Lazaridou, A., Martel, M. O., Cornelius, M., Xu, X., Jamison, R. N., Katz, J. N., Carriere, J., Khanuja, H. P., Sterling, R. S., Smith, M. T., & Haythornthwaite, J. A. (2022). Multimodal prediction of pain and functional outcomes 6 months following total knee replacement: a prospective cohort study. BMC Musculoskeletal Disorders, 23(1). https://doi.org/10.1186/s12891-022-05239-3
Evans, J. T., Walker, R. W., Evans, J. P., Blom, A. W., Sayers, A., & Whitehouse, M. R. (2019). How long does a knee replacement last? A systematic review and meta-analysis of case series and national registry reports with more than 15 years of follow-up. The Lancet, 393(10172), 655–663. https://doi.org/10.1016/s0140-6736(18)32531-5
Fatoye, F., Yeowell, G., Wright, J. M., & Gebrye, T. (2021). Clinical and cost-effectiveness of physiotherapy interventions following total knee replacement: a systematic review and meta-analysis. In Archives of Orthopaedic and Trauma Surgery (Vol. 141, Issue 10, pp. 1761–1778). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/s00402-021-03784-5
Ferket, B. S., Feldman, Z., Zhou, J., Oei, E. H., Bierma-Zeinstra, S. M. A., & Mazumdar, M. (2017). Impact of total knee replacement practice: Cost effectiveness analysis of data from the Osteoarthritis Initiative. BMJ (Online), 356. https://doi.org/10.1136/bmj.j1131
Hasenauer, M. D., Ho, H., & Engh, C. A. (2022). Factors Associated With the Incidence and Timing of Total Knee Arthroplasty Infection. Journal of Arthroplasty, 37(6), S276-S280.e3. https://doi.org/10.1016/j.arth.2022.02.034
Inoue, D., Xu, C., Yazdi, H., & Parvizi, J. (2019). Age alone is not a risk factor for periprosthetic joint infection. Journal of Hospital Infection, 103(1), 64–68. https://doi.org/10.1016/j.jhin.2019.04.005
James, S. L., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdela, J., Abdelalim, A., Abdollahpour, I., Abdulkader, R. S., Abebe, Z., Abera, S. F., Abil, O. Z., Abraha, H. N., Abu-Raddad, L. J., Abu-Rmeileh, N. M. E., Accrombessi, M. M. K., … Murray, C. J. L. (2018). Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet, 392(10159), 1789–1858. https://doi.org/10.1016/S0140-6736(18)32279-7
Kigera JWM; Kimpiatu P. (2015). Incidence of Early Post Operative Infection after Primary Total Knee Arthroplasty at an East African Centre. The ANNALS of AFRICAN SURGERY, 12(2). www.annalsofafricansurgery.com
Konnyu, K. J., Thoma, L. M., Cao, W., Aaron, R. K., Panagiotou, O. A., Bhuma, M. R., Adam, G. P., Balk, E. M., & Pinto, D. (2023). Rehabilitation for Total Knee Arthroplasty: A Systematic Review. American Journal of Physical Medicine and Rehabilitation, 102(1), 19–33. https://doi.org/10.1097/PHM.0000000000002008
Kremers, H. M., Larson, D. R., Crowson, C. S., Kremers, W. K., Washington, R. E., Steiner, C. A., Jiranek, W. A., & Berry, D. J. (2014). Prevalence of total hip and knee replacement in the United States. Journal of Bone and Joint Surgery - American Volume, 97(17), 1386–1397. https://doi.org/10.2106/JBJS.N.01141
L. Snell, D., Hipango, J., Sinnott, K. A., Dunn, J. A., Rothwell, A., Hsieh, C. J., DeJong, G., & Hooper, G. (2018). Rehabilitation after total joint replacement: a scoping study. In Disability and Rehabilitation (Vol. 40, Issue 14, pp. 1718–1731). Taylor and Francis Ltd. https://doi.org/10.1080/09638288.2017.1300947
Li, S., Si, H., Zhang, S., Xu, J., Liu, Y., & Shen, B. (2023). Does diabetes mellitus impair the clinical results of total knee arthroplasty under enhanced recovery after surgery? Journal of Orthopaedic Surgery and Research, 18(1). https://doi.org/10.1186/s13018-023-03982-4
Lum, Z. C., Natsuhara, K. M., Shelton, T. J., Giordani, M., Pereira, G. C., & Meehan, J. P. (2018). Mortality During Total Knee Periprosthetic Joint Infection. Journal of Arthroplasty, 33(12), 3783–3788. https://doi.org/10.1016/j.arth.2018.08.021
Mehta, S., Rigney, A., Webb, K., Wesney, J., Stratford, P. W., Shuler, F. D., & Oliashirazi, A. (2020). Characterizing the recovery trajectories of knee range of motion for one year after total knee replacement. Physiotherapy Theory and Practice, 36(1), 176–185. https://doi.org/10.1080/09593985.2018.1482980
Nizam, I., Batra, A., & Gogos, S. (2019). Early resumption of driving within 3 weeks following patient-specific instrumented total knee arthroplasty: An evaluation of 160 cases. Journal of ISAKOS, 4(2), 88–92. https://doi.org/10.1136/jisakos-2018-000268
Nyagah Caleb. (2023). EARLY OUTCOMES OF PRIMARY TOTAL KNEE REPLACEMENT: A MULTICENTER STUDY.
Picard, F., Deakin, A., Balasubramanian, N., & Gregori, A. (2018). Minimally invasive total knee replacement: techniques and results. In European Journal of Orthopaedic Surgery and Traumatology (Vol. 28, Issue 5, pp. 781–791). Springer-Verlag France. https://doi.org/10.1007/s00590-018-2164-4
Price, A. J., Alvand, A., Troelsen, A., Katz, J. N., Hooper, G., Gray, A., Carr, A., & Beard, D. (2018). Hip and knee replacement 2 Knee replacement. In www.thelancet.com (Vol. 392). www.thelancet.com
Pua, Y. H., Poon, C. L. L., Seah, F. J. T., Thumboo, J., Clark, R. A., Tan, M. H., Chong, H. C., Tan, J. W. M., Chew, E. S. X., & Yeo, S. J. (2019). Predicting individual knee range of motion, knee pain, and walking limitation outcomes following total knee arthroplasty. Acta Orthopaedica, 90(2), 179–186. https://doi.org/10.1080/17453674.2018.1560647
Shah, A., Memon, M., Kay, J., Wood, T. J., Tushinski, D. M., & Khanna, V. (2019). Preoperative Patient Factors Affecting Length of Stay following Total Knee Arthroplasty: A Systematic Review and Meta-Analysis. Journal of Arthroplasty, 34(9), 2124-2165.e1. https://doi.org/10.1016/j.arth.2019.04.048
Spichler-Moffarah, A., Rubin, L. E., Bernstein, J. A., O’Bryan, J., McDonald, E., & Golden, M. (2023). Prosthetic Joint Infections of the Hip and Knee Among the Elderly: A Retrospective Study. American Journal of Medicine, 136(1), 100–107. https://doi.org/10.1016/j.amjmed.2022.08.006
Sveinsdóttir, H., Kristiansen, K., & Skúladóttir, H. (2021). Health related quality of life in patients having total knee replacement and associations with symptoms, recovery, and patient education: A six month follow up study. International Journal of Orthopaedic and Trauma Nursing, 42. https://doi.org/10.1016/j.ijotn.2020.100830
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