EFFECTS OF A SELECTED HERBAL BEVERAGE ON THE FULL HAEM OGRAM, INFLAMMATION AND SERUM ZINC STATUS OF HIV AND AIDS SUBJECTS IN NAIROBI, KENYA, 2010

Authors

  • Friederike Deborah Nagel Jomo Kenyatta University of Agriculture and Technology
  • Prof. Charles F.L. Mbakaya Rongo University College, School of Physical Sciences
  • Dr. Yeri I. Kombe Kenya Medical Research Institute
  • Dr. Venny C. S. Nyambati Jomo Kenyatta University of Agriculture and Technology

Keywords:

Haemogram, placebo, chronic inflammation

Abstract

Purpose: The purpose of the study was to establish the effects of a selected herbal beverage on the full Haemogram, inflammation and serum zinc status of HIV and AIDS Subjects in Nairobi, Kenya.

Methodology: This was a randomized prospective controlled intervention study. The sample size was 100 patients who were recruited from the Association of People living With AIDS in Kenya (TAPWAK) that is based at Nairobi West. The study subjects were recruited upon consent and randomized into the two groups, one group received the herbal beverage and the other a placebo. The intervention was double blinded and unmasking was done during data analysis. Blood samples were taken from the subjects at baseline and periodically, to investigate effects on or changes in the above biomarkers. Means and medians of the biomarkers were compared between and within groups at baseline and at end line.

Results: Following the study findings it was possible to conclude that regarding the socio-economic status of the study subjects in both arms were comparable by marital status. Majority of subjects had children who depended on them. By education status, the subjects were comparable between the groups. Most of the subjects had attained some level of education, those on the intervention arm having a higher proportion of more educated persons. While about half the subjects had social support systems, financial support was lacking for close to 80% of the subjects in both arms. Women were a majority in both study arms, one reason could be that they are more willing to get help for issues affecting their health. The Erythrocyte Sedimentation Rate (ESR) count was not different at baseline in both groups but almost attained significant difference at the 9th month of intervention, the intervention group having a much lower value (p = 0.074), suggesting that the mode of action of the herbal beverage was via reduction of inflammation. The same was the trend in the Mean Corpuscular Hemoglobin Concentration MCHC, the intervention arm having a lower value than the placebo group (p = 0.088). However, the other hematological parameters were neither different at baseline nor at the 9th month of intervention. The serum zinc values in the intervention and placebo arms were similar at baseline, 3rd, 6th and 9th months and lower than normal values at all time points, suggesting that the intervention had no benefits in repletion of serum zinc levels and / or no effect in improved absorption of serum zinc of the subjects, yet this trace element is critical in human immunity. The median platelet (PLT) count was much lower in the intervention arm than the placebo at the 9th month of intervention (p = 0.045) while they were not different at baseline (p = 0.332), again suggesting that the mode of action of the herbal beverage might be via PLT reduction.  Overall, the benefits of the herbal beverage were only marginally better in the intervention arm than the placebo for most of the selected biomarkers assessed in this study.

Unique contribution to theory, practice and policy: The study recommended that despite interesting finding regarding the impact of the ESR count of patients of the intervention group which could suggest that consumption of the herbal beverage in combination with an effective medical based treatment of HIV/ Aids could be promising for improvement of inflammation regulation in the patients. Further studies on that would be of benefit.

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Author Biographies

Friederike Deborah Nagel, Jomo Kenyatta University of Agriculture and Technology

post graduate student

Prof. Charles F.L. Mbakaya, Rongo University College, School of Physical Sciences

Lecturer

Dr. Yeri I. Kombe, Kenya Medical Research Institute

Center for Public Health Research, (CPHR - KEMRI)

Dr. Venny C. S. Nyambati, Jomo Kenyatta University of Agriculture and Technology

Lecturer

References

Dannhauser, A., Van Staden, A. M., Van der Ryst, E., Nel, M., Marais, N., Erasmus, E., ... & Le Roux, G. D. (1999). Nutritional status of HIV-1 seropositive patients in the Free State Province of South Africa: anthropometric and dietary profile. European journal of clinical nutrition, 53(3), 165-173.

Erhabor O, Ejele OA, Nwauche CA, Buseri FI. Some haematological parameters in human immunodeficiency virus (HIV) infected Africans: the Nigerian perspective. Niger J Med. 2005 Jan-Mar;14(1):33-8.

Friis, H., & Michaelsen, K. F. (1998). Micronutrients and HIV infection: a review. European Journal of Clinical Nutrition, 52(3), 157-163.Graham NM, Sorensen D, Odaka N, Brookmeyer R, Chan D, Willet WC, Morris JS, Saah AJ. Relationship of Serum Copper and Zinc Levels to HIV-1 Seropositivity and Progression to AIDS. J. Acquir Immune Defic Syndr. 1991; 4 (10): 976-980

Grimble, R. F. (1998). Nutritional modulation of cytokine biology. Nutrition, 14(7), 634-640.

Joint United Nations Programme on HIV/AIDS. (2006). Overview of the global AIDS epidemic. Report on the global AIDS epidemic, 2006, 8-50.

Mbakaya, C. F. L., & Wakori, E. W. T. (1997). Management of HIV/AIDS: The zinc-dioxin synergy. Medical Review, 3(3), 2-5.

Ndakotsu, M. A., Salawu, L., & Durosinmi, M. A. (2009). Relation between erythrocyte sedimentation rate, clinical and immune status in HIV infected patients. Nigerian Journal of Medicine, 17(4), 420-422.

Ndakotsu, M. A., Salawu, L., & Durosinmi, M. A. (2009). Relation between erythrocyte sedimentation rate, clinical and immune status in HIV infected patients. Nigerian Journal of Medicine, 17(4), 420-422.

Niyongabo, T., Henzel, D., Ndayishimyie, J. M., Melchior, J. C., Ndayiragije, A., Ndihokubwayo, J. B., ... & Larouze, B. (1999). Nutritional status of adult inpatients in Bujumbura, Burundi (impact of HIV infection). European journal of clinical nutrition, 53(7), 579-582.

Oguntibeju, O. O., Van Schalkwyk, F. E., Heever, W. D., & Veldman, F. J. (2003). Importance of vitamin and mineral supplementation in HIV/AIDS patients to improve their nutritional and immunological status. Pakistan Journal of Medical Sciences, 19(3), 217-219.

Oguntibejud, O. O., van den Heever, W. M., & Van Schalkwyk, F. E. (2005). An analysis of the baseline dietary intake of HIV-positive/AIDS patients. Medical Technology SA, 19(2), 3-9.

Parinitha, S. S., & Kulkarni, M. H. (2012). Haematological changes in HIV infection with correlation to CD4 cell count. The Australasian medical journal, 5(3), 157.

Ripa, S., & Ripa, R. (1994). Zinc and immune function. Minerva medica, 86(7-8), 315-318.Jul-Aug; 86 (7-8): 315-318

Schwarz, K. B. (1996). Oxidative stress during viral infection: a review. Free Radical Biology and Medicine, 21(5), 641-649..

Semba, R. D., & Tang, A. M. (1999). Micronutrients and the pathogenesis of human immunodeficiency virus infection. British Journal of Nutrition, 81(03), 181-189.

Sinha, S. N., & Gabrieli, E. R. (1970). Serum copper and zinc levels in various pathologic conditions. American journal of clinical pathology, 54(4), 570-577.

Sprietsma, J. E. (1999). Modern diets and diseases: NO-zinc balance. Medical hypotheses, 53(1), 6-16.

Tang, A. M., Graham, N. M., Kirby, A. J., McCall, L. D., Willett, W. C., & Saah, A. J. (1993). Dietary Micronutrient Intake and Risk of Progression to Acquired Immunodeficiency Syndrome (AIDS) in Human Immunodeficiency Virus Type 1 (HlV-1)-infected Homosexual Men. American Journal of Epidemiology, 138(11), 937-951.

Thurnham, D. I., Mburu, A. S., Mwaniki, D. L., Muniu, E. M., Alumasa, F., & de Wagt, A. (2008). Using plasma acute-phase protein concentrations to interpret nutritional biomarkers in apparently healthy HIV-1-seropositive Kenyan adults. British journal of nutrition, 100(01), 174-182.

Timbo, B. B., & Tollefson, L. (1994). Nutrition: a cofactor in HIV disease. Journal of the American Dietetic Association, 94(9), 1018-1022.

Walter RM, Oster M, Lee TJ et al. Zinc Status in Human Immunodeficiency Virus Infection. Life Sci 1990, 46: 1597-1600

Weber, R., Christen, L., Loy, M., Schaller, S., Christen, S., Joyce, C. R., ... & Cohen, M. R. (1999). Randomized, placebo-controlled trial of Chinese herb therapy for HIV-1-infected individuals. JAIDS Journal of Acquired Immune Deficiency Syndromes, 22(1), 56-64.

Wellinghausen, N., Kern, W. V., Jöchle, W., & Kern, P. (2000). Zinc serum level in human immunodeficiency virus-infected patients in relation to immunological status. Biological trace element research, 73(2), 139-149.

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Published

2016-11-16

How to Cite

Nagel, F. D., Mbakaya, P. C. F., Kombe, D. Y. I., & Nyambati, D. V. C. S. (2016). EFFECTS OF A SELECTED HERBAL BEVERAGE ON THE FULL HAEM OGRAM, INFLAMMATION AND SERUM ZINC STATUS OF HIV AND AIDS SUBJECTS IN NAIROBI, KENYA, 2010. Global Journal of Health Sciences, 1(2), 13–26. Retrieved from https://iprjb.org/journals/index.php/GJHS/article/view/186

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