"Accepting "˜Eternity' of Antiretroviral Drugs": A Pillar in Improving Adherence to Antiretroviral Drugs among a Selected Population of HIV Positive Patients in a Semi-Urban Region in Kenya - A Qualitative Analytic Study

Authors

  • Martin Owuor Ochieng Jomo Kenyatta University of Agriculture and Technology
  • Prof. Gideon Kikuvi Jomo Kenyatta University of Agriculture and Technology
  • Dr. Daniel Mokaya Jomo Kenyatta University of Agriculture and Technology

DOI:

https://doi.org/10.47604/gjhs.1810

Keywords:

Adherence, Stigma, Acceptance, Social Support

Abstract

Purpose: The objective of this research was to ascertain perspectives on suboptimal adherence and ways to improve optimal adherence to antiretroviral drugs (ARVs) among Human Immunodeficiency Virus (HIV) positive patients attending selected HIV Care Centres in Kibwezi West Sub-county, Makueni County, Kenya.

Methodology: Six Focused Group Discussions (FGD) homogeneously stratified by age and gender and four Key Informant Interviews (KII) were conducted. Each FGD consisted of 8 study participants recruited by purposive sampling technique.

Findings: Focus group discussions identified fear, stigma, defiance, ignorance on reasons for medication, not believing in oneself, participating in activities that hinder adherence such as drinking alcohol, retrogressive religious beliefs, lack of self-love and denial as the main causes of sub optimal adherence to ARVs. However the discussions also identified one-on-one educational counselling sessions, seeking advice, group education with similar infected people, adherence counselling support by health workers, acceptance of one's status, social and family support as means to improve adherence to ARVs. It also identified knowing one's status, acceptance, personal discipline on adherence and reminders such as clock alarms or a trusted person as means to improve adherence to ARVs. However, the discussions revealed gender and age differences, attributed to different life's challenges and perspectives in the different cohorts thus interventions should be targeted rather than lump sum. Key informant interviews identified ignorance, stigma, busy work schedule and lack of social support as patient level factors that would hinder adherence to ARVs. They also noted long waiting time, distance, poor attitude by health service providers and drug stock outs contributing to poor adherence to ARVs at the facility level. However, they identified community dispensing, support groups, health talks with mentors, psychosocial support, drug availability, outreach, encouraging disclosure, distribution of patients to nearest satellite clinics and directly observed therapy (DOT) by a trusted relative as ways to improve adherence to ARVs.

Unique Contribution to Theory, Practice and Policy: interventions need to be tailored to the specific population and individual needs; thus, adopting better and informed strategies. The study adds to the pool of knowledge that factors affecting adherence are dependent on populations under investigation due to varied socio-demographic, socio-cultural and socio-economic factors locally, regionally and globally. The findings of the study will inform the local county government of Makueni and Kibwezi West Sub-county administrators in formulating local economic and health policies and by-laws that would aid in improving optimal adherence to ARVs.

Downloads

Download data is not yet available.

References

Adejumo, O. A., Malee, K. M., Ryscavage, P., Hunter, S. J., & Taiwo, B. O. (2015). Contemporary issues on the epidemiology and antiretroviral adherence of HIV-infected adolescents in sub-Saharan Africa: a narrative review. Journal of the International AIDS Society, 16(18), 1-19. doi: 10.7448/IAS.18.1.20049.

Adeniyi, O. V., Ajayi, A. I., Goon, D. T., Owolabi, E. O., Alfred, E., & Lambert, J. (2018). Factors affecting adherence to antiretroviral therapy among pregnant women in the Eastern Cape, South Africa. BMC Infectious Diseases, 18,175. https://doi.org/10.1186/s12879-018-3087-8.

Agbaji, O. O., Abah, I. O., Falang, K. D., Ebonyi, A. O., Musa, J., Ugoagwu, P., et al. (2015). Treatment Discontinuation in Adult HIV-Infected Patients on First-Line Antiretroviral Therapy in Nigeria. Current HIV research, 13(3), 184-92.

Ankrah, D., Koster, E., Mantel-Teeuwisse, A., Arhinful, D., Agyepong, I., & Lartey, M. (2016). Facilitators and barriers to antiretroviral therapy adherence among adolescents in Ghana. Patient Preference and Adherence, 10, 329-337.

Chirambo, L., Valeta, M., Kamanga, T. M., & Nyondo-Mipando, A. L. (2019). Factors influencing adherence to antiretroviral treatment among adults accessing care from private health facilities in Malawi. BMC Public Health, 19,1382. https://doi.org/10.1186/s12889-019-7768-z.

Daily Nation. (2016, September 16). Kibwana launches ambitious free healthcare plan for Makueni residents. Retrieved March 1, 2018, from Daily Nation:

https://www.nation.co.ke/counties/makueni/Makueni-County-to-offer-free-healthcare-to-residents/1183294-3383768-vwve2o/index.html

DiMatteo, M. R. (2004). Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. Medical Care, 42(3), 200-9.

Falang, K. D., Akubaka, P., & Jimam, N. S. (2012). Patient factors impacting antiretroviral drug adherence in a Nigerian tertiary hospital. Journal of Pharmacology and Pharmacotherapeutics, 3(2), 138-142.doi: 10.4103/0976-500X.95511.

Government of Makueni County. (2017, December 27). Universal Healthcare Promotion. Retrieved March 1, 2018, from Government of Makueni County:

https://www.makueni.go.ke/promoting-makueni-universal-healthcare

Grieb, S. M., Kerrigan, D., Tepper, V., Ellen, J., & Sibinga, E. (2018). The Clinic Environment as a Form of Social Support for Adolescents and Young Adults Living with HIV. AIDS Patient Care & STDS, 32(5), 208-213. doi: 10.1089/apc.2018.0012.

Hanif, H., Bastos, F., Malta, M., Bertoni, N., Surkan, P., Winch, P. J., et al. (2013). Individual and contextual factors of influence on adherence to antiretrovirals among people attending public clinics in Rio de Janeiro, Brazil. BMC Public Health, 13 (1), 1-10. doi: 10.1186/1471-2458-13-574.

Heestermans, T., Browne, J., Aitken, S., Vervoort, S., & Klipstein-Grobusch, K. (2016). Determinants of adherence to antiretroviral therapy among HIV-positive adults in sub-Saharan Africa: a systematic review. BMJ Global Health, 1(4), 1-25. doi: 10.1136/bmjgh-2016-000125.

Institute for Health Metrics and Evaluation. (2019). Kenya - Makueni. Retrieved September 2022, 30, from Institute for Health Metrics and Evaluation: https://www.healthdata.org/kenya-makueni

Joint United Nations On AIDS [UNAIDS]. 2021, Global HIV & AIDS statistics "” 2020 fact sheet .Retrieved April 23, 2021, from Joint United Nations On AIDS [UNAIDS]: https://www.unaids.org/en/resources/fact-sheet

Kim , M. H., Mazenga, A. C., Yu, X., Ahmed, S., Paul , M. E., Kazembe, P. N., et al. (2017). High self-reported non-adherence to antiretroviral therapy amongst adolescents living with HIV in Malawi: barriers and associated factors. Journal of the International AIDS Society, 20(1), 1-12. doi: 10.7448/IAS.20.1.21437.

Ministry of Health [MoH]. (2014). Kenya Aids Strategic Framework 2014/2015-2018/2019. Nairobi: Ministry of Health [MoH].

Ministry of Health. (2020). Kenya Population-based HIV Impact Assessment (KENPHIA). Retrieved 29 March, 2020 from Ministry of Health: http://www.health.go.ke/wp-content/uploads/2020/02/KENPHIA-2018-PREL-REP-2020-HR3-final.pdf.

Mukui, I. N., Ng'ang'a, L., Williamson, J., Wamicwe, J. N., Vakil, S., Katana, A., et al. (2016). Rates and Predictors of Non-Adherence to Antiretroviral Therapy among HIV-Positive Individuals in Kenya: Results from the Second Kenya AIDS Indicator Survey, 2012. PLoS ONE, 11(12). doi: 10.1371/journal.pone.0167465.

National AIDS Control Council. (2016). Kenya HIV County Profiles 2016. Nairobi: Ministry of Health.

Nozaki, ,. I., Dube, C., Kakimoto, K., Yamada, N., & Simpungwe, J. B. (2011). Social factors affecting ART adherence in rural settings in Zambia. AIDS Care, 23(7), 831-838. doi: 10.1080/09540121.2010.542121.

Nozipho, B., Cordeiro, L., Poudel, K., Sibiya, T., Sayer, A., & Sibeko , L. (2020). Individual, household, and community level barriers to ART adherence among women in rural Eswatini. PLoS One, 15(4). doi: 10.1371/journal.pone.0231952. eCollection 2020.

Rosenblum, M., Deeks, S. G., Laan, M. V., & Bangsberg, D. R. (2009). The Risk of Virologic Failure Decreases with Duration of HIV Suppression, at Greater than 50% Adherence to Antiretroviral Therapy. PLoS ONE, 4(9), 1-7.

doi.org/10.1371/journal.pone.0007196.

Rouhani, S. A., O'Laughlin, K. N., Faustin, Z. M., Tsai, A. C., Kasozi, J., & Ware, N. C. (2017). The role of social support on HIV testing and treatment adherence: A qualitative study of HIV-infected refugees in southwestern Uganda. Global Public Health, 12(8), 1051-1064. doi: 10.1080/17441692.2015.1132472.

Semvua, S. K., Orrell, C., Mmbaga, B. T., Semvua, H. H., Bartlett, J. A., & Boulle, A. A. (2017). Predictors of non-adherence to antiretroviral therapy among HIV infected patients in northern Tanzania. PLoS One, 12(12), 1-17.

doi: 10.1371/journal.pone.0189460.

Strauss, M., George, G., Lansdell, E., Mantell, J., Govender, K., Romo, M., et al. (2018). HIV testing preferences among long distance truck drivers in Kenya: a discrete choice experiment. AIDS Care, 30(1), 72-80.doi: 10.1080/09540121.2017.1367086.

Tandon, N., Mao, J., Shprecher, A., Anderson, A. J., Cao, F., Jiao, X., et al. (2019). Compliance with clinical guidelines and adherence to antiretroviral therapy among patients living with HIV. Current Medical Research & Opinion, 35(1), 63-67. doi: 10.1080/03007995.2018.1519499.

van Wyk, B., & Davids, L,A. (2019). Challenges to HIV treatment adherence amongst adolescents in a low socio-economic setting in Cape Town. Southern African Journal of HIV Medicine, 20(1), 1002.

World Health Organisation [WHO]. (2020). SDG 3: Ensure healthy lives and promote wellbeing for all at all ages. Retrieved March 1, 2018, from World Health Organisation [WHO]: http://www.who.int/sdg/targets/en/

Downloads

Published

2023-03-04

How to Cite

Ochieng, M., Kikuvi, G., & Mokaya, D. (2023). "Accepting "˜Eternity’ of Antiretroviral Drugs": A Pillar in Improving Adherence to Antiretroviral Drugs among a Selected Population of HIV Positive Patients in a Semi-Urban Region in Kenya - A Qualitative Analytic Study. Global Journal of Health Sciences, 8(2), 1–10. https://doi.org/10.47604/gjhs.1810

Issue

Section

Articles