Influence of Environmental Factors on Embryonic Development and Fetal Programming in South Africa

Authors

  • Michael Lubanzi North-West University

DOI:

https://doi.org/10.47604/ijb.2500

Keywords:

Environmental Factors, Embryonic Development, Fetal Programming

Abstract

Purpose: The aim of the study was to investigate the influence of environmental factors on embryonic development and fetal programming

Methodology: This study adopted a desk methodology. A desk study research design is commonly known as secondary data collection. This is basically collecting data from existing resources preferably because of its low cost advantage as compared to a field research. Our current study looked into already published studies and reports as the data was easily accessed through online journals and libraries.

Findings: The study revealed compelling evidence linking various environmental exposures, including air pollution, maternal nutrition, smoking, stress, chemical contaminants, and heavy metals, to adverse pregnancy outcomes and long-term health consequences for offspring. The study also highlighted the critical role of epigenetic modifications, such as DNA methylation, histone modifications, and non-coding RNA expression, in mediating the effects of environmental factors on gene expression and cellular function during embryogenesis.

Unique Contribution to Theory, Practice and Policy: Developmental Origins of Health and Disease (DOHaD) theory & Fetal Programming theory may be used to anchor future studies on the influence of environmental factors on embryonic development and fetal programming. Incorporate comprehensive assessments of environmental exposures into routine prenatal care. Healthcare providers should consider factors such as maternal diet, smoking status, stress levels, chemical exposures, and air quality when counseling pregnant individuals. Advocate for stricter environmental regulations aimed at reducing exposure to air pollutants, endocrine-disrupting chemicals, heavy metals, and other harmful substances during pregnancy. Tailor interventions based on individual risk profiles and environmental exposures. For example, provide targeted nutritional counseling, smoking cessation programs, stress management support, and referrals for environmental health assessments as part of prenatal care services.

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References

Ahmadzai, M., Yousufzai, A., & Stanikzai, F. H. (2018). Afghanistan: Mortality Survey 2018. United Nations Assistance Mission in Afghanistan (UNAMA). Retrieved from https://www.unama.unmissions.org/sites/default/files/unama_report_on_mortality_survey_2018_-_english.pdf

Artiga, S., Hill, L., & Orgera, K. (2020). Key Facts on Health and Health Care by Race and Ethnicity. Kaiser Family Foundation. Retrieved from https://www.kff.org/racial-equity-and-health-policy/issue-brief/key-facts-on-health-and-health-care-by-race-and-ethnicity/

Balogun, M., Oyeniran, A. A., Oyeyemi, A. S., Adewoyin, A. S., Abdur-Rahman, L. O., Salaudeen, A. G., Abdulganiyu, O., & Ahmed, P. (2021). Trends and determinants of maternal mortality in Nigeria: A systematic review and meta-analysis. BMC Pregnancy and Childbirth, 21(1), 243. https://doi.org/10.1186/s12884-021-03692-0

Barker, D. J. (1990). The fetal and infant origins of adult disease. BMJ, 301(6761), 1111. https://doi.org/10.1136/bmj.301.6761.1111

Barker, D. J. (1995). Fetal origins of coronary heart disease. BMJ, 311(6998), 171-174. https://doi.org/10.1136/bmj.311.6998.171

Barker, D. J. (1998). Mothers, babies, and health in later life. 2nd edition. Churchill Livingstone.

Barker, D. J. (2007). The origins of the developmental origins theory. Journal of Internal Medicine, 261(5), 412-417. https://doi.org/10.1111/j.1365-2796.2007.01809.x

Barker, D. J. (2007). The origins of the developmental origins theory. Journal of Internal Medicine, 261(5), 412-417. https://doi.org/10.1111/j.1365-2796.2007.01809.x

Bhutta, Z. A., Ahmed, T., Black, R. E., Cousens, S., Dewey, K., Giugliani, E., Haider, B. A., Kirkwood, B., Morris, S. S., Sachdev, H. P. S., & Shekar, M. (2010). What works? Interventions for maternal and child undernutrition and survival. The Lancet, 371(9610), 417-440. https://doi.org/10.1016/S0140-6736(07)61693-6

Black, R. E., Victora, C. G., Walker, S. P., Bhutta, Z. A., Christian, P., de Onis, M., Ezzati, M., Grantham-McGregor, S., Katz, J., Martorell, R., & Uauy, R. (2013). Maternal and child undernutrition and overweight in low-income and middle-income countries. The Lancet, 382(9890), 427-451. https://doi.org/10.1016/S0140-6736(13)60937-X

Braun, J. M., Bellinger, D. C., Hauser, R., Wright, R. O., Chen, A., Calafat, A. M., & Lanphear, B. P. (2016). Association of environmental toxicants and adverse pregnancy outcomes: A systematic review and meta-analysis. Environmental Health Perspectives, 124(6), 856-865. https://doi.org/10.1289/ehp.1409073

Braun, J. M., Messerlian, C., Hauser, R., & Mínguez-Alarcón, L. (2017). Environmental contaminants and adverse pregnancy outcomes. Fertility and Sterility, 107(4), 817-823. https://doi.org/10.1016/j.fertnstert.2017.02.120

Braveman, P., Egerter, S., & Williams, D. R. (2010). The social determinants of health: Coming of age. Annual Review of Public Health, 32, 381-398. https://doi.org/10.1146/annurev.publhealth.031809.131255

Burke, H., Leonardi-Bee, J., Hashim, A., Pine-Abata, H., Chen, Y., & Cook, D. G. (2017). Prenatal and passive smoke exposure and incidence of asthma and wheeze: Systematic review and meta-analysis. Pediatrics, 139(4), e20164006. https://doi.org/10.1542/peds.2016-4006

Central Statistical Agency [Ethiopia], ICF, & USAID. (2019). Ethiopia Demographic and Health Survey 2016. Retrieved from https://dhsprogram.com/pubs/pdf/FR328/FR328.pdf

Desai, M., ter Kuile, F. O., Nosten, F., McGready, R., Asamoa, K., Brabin, B., Newman, R. D., & Menendez, C. (2020). Epidemiology and burden of malaria in pregnancy. The Lancet Infectious Diseases, 7(2), 93-104. https://doi.org/10.1016/S1473-3099(07)70021-X

Diamanti-Kandarakis, E., Bourguignon, J. P., Giudice, L. C., Hauser, R., Prins, G. S., Soto, A. M., Zoeller, R. T., & Gore, A. C. (2009). Endocrine-disrupting chemicals: An Endocrine Society scientific statement. Endocrine Reviews, 30(4), 293-342. https://doi.org/10.1210/er.2009-0002

Egami, K., Fujiwara, T., Kawachi, I., & Suzuki, T. (2017). Association of maternal access to civil rights with low-birthweight births in African-American women. Social Science & Medicine, 190, 180-186. https://doi.org/10.1016/j.socscimed.2017.08.029

Gaillard, R., Steegers, E. A., Duijts, L., Felix, J. F., Hofman, A., Franco, O. H., & Jaddoe, V. W. (2016). Childhood cardiometabolic outcomes of maternal obesity during pregnancy: The Generation R Study. Hypertension, 63(4), 683-691. https://doi.org/10.1161/hypertensionaha.113.02524

Gloyd, S., Wagenaar, B. H., Woelk, G. B., Kalibala, S., & Mzileni, B. (2021). Opportunities and challenges for strengthening health systems to increase access to skilled maternity care in Ethiopia: The Health Extension Program. Maternal and Child Health Journal, 25(4), 533-540. https://doi.org/10.1007/s10995-020-03040-7

Godfrey, K. M., & Gluckman, P. D. (2010). Early life events and their consequences for later disease: A life history and evolutionary perspective. American Journal of Human Biology, 22(2), 61-71. https://doi.org/10.1002/ajhb.20919

Goyal, N. K., Teeters, A., Ammerman, R. T., & Gelfand, A. (2017). The association of maternal and fetal stress with infant neurodevelopmental outcomes. JAMA Pediatrics, 171(8), 608-615. https://doi.org/10.1001/jamapediatrics.2017.0642

Grandjean, P., & Landrigan, P. J. (2014). Neurobehavioural effects of developmental toxicity. The Lancet Neurology, 13(3), 330-338. https://doi.org/10.1016/S1474-4422(13)70278-3

Gregg, A. R., Gross, S. J., Best, R. G., Monaghan, K. G., Bajaj, K., Skotko, B. G., Thompson, B. H., Watson, M. S., & Johnson, J. M. (2019). ACMG statement on noninvasive prenatal screening for fetal aneuploidy. Genetics in Medicine, 21(5), 961-963. https://doi.org/10.1038/s41436-019-0479-x

Karim, A. M., Tamire, A., Medhanyie, A. A., Betemariam, W., Changes, B., & Betemariam, W. (2019). The effect of community-based health insurance on the utilization of modern health care services in Ethiopia: Evidence from household panel data. BMC Health Services Research, 19(1), 771. https://doi.org/10.1186/s12913-019-4634-7

Krieger, N., Williams, D. R., & Moss, N. E. (2008). Measuring social class in US public health research: Concepts, methodologies, and guidelines. Annual Review of Public Health, 29, 417-438. https://doi.org/10.1146/annurev.publhealth.29.020907.090609

Kumar, A., Misra, R. P., & Dhar, P. L. (2017). Environmental toxicology of emerging contaminants with reference to North India: A review. Journal of Environmental Science and Health, Part C, 35(2), 75-122. https://doi.org/10.1080/10590501.2017.1282478

Landrigan, P. J., Fuller, R., Acosta, N. J. R., Adeyi, O., Arnold, R., Basu, N., Bald, A. B., Bertollini, R., Bose-O'Reilly, S., Boufford, J. I., Breysse, P. N., Chiles, T., Mahidol, C., Coll-Seck, A. M., Cropper, M. L., Fobil, J., Fuster, V., Greenstone, M., Haines, A., "¦ Zhong, M. (2018). The Lancet Commission on pollution and health. The Lancet, 391(10119), 462-512. https://doi.org/10.1016/S0140-6736(17)32345-0

Li, X., Huang, S., Jiao, A., & Yang, X. (2016). Association between maternal exposure to air pollution and risk of congenital heart defects in offspring: A population-based case-control study. Environmental Health, 15(1), 97. https://doi.org/10.1186/s12940-016-0184-2Top of Form

Martin, J. A., Hamilton, B. E., Osterman, M. J. K., Driscoll, A. K., & Drake, P. (2020). Births: Final data for 2019. National Vital Statistics Reports, 70(2), 1-51. Retrieved from https://www.cdc.gov/nchs/data/nvsr/nvsr70/nvsr70-02-508.pdf

Ministry of Health, Labour and Welfare, Japan. (2020). Promotion of Maternal and Child Health. Retrieved from https://www.mhlw.go.jp/english/wp/wp-hw4/dl/2-074.pdf

Mori, R., Yonemoto, N., Noma, H., Ochirbat, T., Barber, E., & Akashi, H. (2021). Health equity and access to maternal and child health services in Mongolia: Findings from the National Maternal and Child Health Services Coverage Survey. BMC Health Services Research, 21(1), 132. https://doi.org/10.1186/s12913-021-06177-4

Office for National Statistics. (2021). Birth characteristics in England and Wales: 2020. Retrieved from https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/livebirths/bulletins/birthcharacteristicsinenglandandwales/2020

Oken, E., Kleinman, K. P., Rich-Edwards, J., & Gillman, M. W. (2018). Maternal prenatal diet and offspring growth and development: A prospective cohort study in 97,382 mother-child pairs from the United Kingdom. British Medical Journal, 361, k1961. https://doi.org/10.1136/bmj.k1961

Olds, D. L., Kitzman, H., Knudtson, M. D., Anson, E., Smith, J. A., & Cole, R. (2007). Effect of home visiting by nurses on maternal and child mortality: Results of a 2-decade follow-up of a randomized clinical trial. JAMA Pediatrics, 161(8), 793-800. https://doi.org/10.1001/archpedi.161.8.793

Public Health England. (2021). Screening tests for you and your baby. Retrieved from https://www.nhs.uk/pregnancy/related-conditions/screening-tests-for-you-and-your-baby/

Sanders, A. P., Claus Henn, B., Wright, R. O., & Perzanowski, M. S. (2015). Association between prenatal lead exposure and gray matter volume in preschool children. Journal of the American Medical Association, 313(9), 919-928. https://doi.org/10.1001/jama.2015.0892

Sychareun, V., Phommachanh, S., Soysouvanh, S., Lee, C. Y. S., Kang, M., & Oh, J. (2017). Cultural beliefs and traditional rituals about child birth practices in Lao PDR. PLoS ONE, 12(7), e0181740. https://doi.org/10.1371/journal.pone.0181740

UNFPA. (2021). Somalia: Maternal Health Dashboard. Retrieved from https://somalia.unfpa.org/en/node/16330

UNICEF. (2019). Clear the air for children: The impact of air pollution on children. Retrieved from https://www.unicef.org/reports/air-pollution-impact-on-children

UNICEF. (2020). The State of the World's Children 2019. Retrieved from https://www.unicef.org/reports/state-of-worlds-children-2019

UNICEF. (2021). Maternal and Newborn Health Disparities. Retrieved from https://data.unicef.org/resources/maternal-newborn-health-disparities/

United Nations. (2020). Sustainable Development Goals: Goal 3 - Good Health and Well-being. Retrieved from https://www.un.org/sustainabledevelopment/health/

WHO. (2020). Maternal mortality. Retrieved from https://www.who.int/news-room/fact-sheets/detail/maternal-mortality

World Bank. (2020). Maternal mortality ratio (modeled estimate, per 100,000 live births). Retrieved from https://data.worldbank.org/indicator/SH.STA.MMRT?locations=ZG

World Bank. (2021). World Development Indicators. Retrieved from https://databank.worldbank.org/source/world-development-indicators

World Health Organization. (2019). WHO recommendations on antenatal care for a positive pregnancy experience. Retrieved from https://www.who.int/reproductivehealth/publications/maternal_perinatal_health/anc-positive-pregnancy-experience/en/

Yaya, S., Uthman, O. A., Amouzou, A., Bishwajit, G., & Massaquoi, T. A. (2020). Why some women fail to give birth at health facilities: A comparative study between Ethiopia and Nigeria. PLoS ONE, 15(6), e0233593. https://doi.org/10.1371/journal.pone.0233593

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Published

2024-04-22

How to Cite

Lubanzi, M. (2024). Influence of Environmental Factors on Embryonic Development and Fetal Programming in South Africa. International Journal of Biology, 4(1), 11–23. https://doi.org/10.47604/ijb.2500

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