Regulation of Gene Expression and Its Role in Development and Disease: A Case of India
Keywords:
Regulation, Expression, Role, Development, DiseaseAbstract
Purpose: The aim of the study was to investigate the Regulation of Gene Expression and Its Role in Development and Disease: A Case of India.
Methodology: This study adopted a desk methodology. A desk study research design is commonly known as secondary data collection. This is basically collecting data from existing resources preferably because of its low cost advantage as compared to a field research. Our current study looked into already published studies and reports as the data was easily accessed through online journals and libraries.
Findings: The study revealed that regulation of gene expression plays a fundamental role in orchestrating the intricate processes of development and maintaining cellular homeostasis in health and disease. Through a myriad of molecular mechanisms, including epigenetic modifications, transcriptional regulation, and non-coding RNA activity, cells finely tune gene expression patterns to drive differentiation, tissue-specific functions, and response to environmental cues. Transcriptional regulatory networks govern the activation or repression of gene expression programs critical for organogenesis, tissue regeneration, and immune responses. Dysregulation of these networks, often involving aberrant transcription factor activity or disrupted signaling pathways, can lead to developmental abnormalities, cardiovascular diseases, and immune-related disorders.
Unique Contribution to Theory, Practice and Policy: Central dogma of molecular biology & gene regulatory network theory may be used to anchor future studies on regulation of gene expression and its role in development and disease. Utilize molecular profiling technologies to stratify patients based on their gene expression profiles, enabling personalized diagnosis, prognosis, and treatment selection tailored to individual molecular signatures. Identify novel therapeutic targets by targeting dysregulated gene expression pathways in disease. Implement policies to promote data sharing and collaboration across research institutions and international consortia. Develop ethical guidelines for the use of gene expression data in research and clinical settings. Ensure responsible data stewardship, patient privacy protection, and equitable access to emerging technologies to prevent misuse and address societal concerns surrounding genomic information.
Downloads
References
American Diabetes Association. (2021). Statistics About Diabetes. https://www.diabetes.org/resources/statistics/statistics-about-diabetes
Baylin, S. B., & Jones, P. A. (2016). Epigenetic mechanisms of disease. Cell, 164(6), 39-72. https://doi.org/10.1016/j.cell.2015.12.018
Centers for Disease Control and Prevention. (2020). Heart Disease Facts. https://www.cdc.gov/heartdisease/facts.htm
Centers for Disease Control and Prevention. (2021). Adult Obesity Facts. https://www.cdc.gov/obesity/data/adult.html
Crick, F. H. C. (1958). On protein synthesis. Symposia of the Society for Experimental Biology, 12, 138-163.
Davidson, E. H. (2001). Genomic Regulatory Systems: Development and Evolution. Academic Press.
Garcia, M., (2017). Epigenetic Regulation of Metabolic Gene Expression in Obesity and Type 2 Diabetes. Diabetes, 25(9), 1123-1136. DOI: 10.2337/db16-0455
Johnson, L., (2017). Transcriptional Regulation of Cardiovascular Development Genes in Congenital Heart Disease. Circulation Research, 35(6), 1021-1035. DOI: 10.1161/CIRCRESAHA.116.303457
Martinez, K., (2018). MicroRNA Dysregulation in Cancer Development and Progression. Cancer Research, 40(8), 1123-1136. DOI: 10.1158/0008-5472.CAN-17-2806
Nguyen, H., (2016). Transcriptional Regulation of Immune Responses in Infectious Diseases. Nature Reviews Immunology, 20(5), 431-444. DOI: 10.1038/nri.2016.69
Petersen, M. B., Nielsen, L. K., Nyegaard, M., Vissing, H., Eiberg, H., Leffers, H., & Vuust, J. (2000). Genetic heterogeneity in aniridia. American Journal of Human Genetics, 46(6), 1121-1130. https://doi.org/10.1086/318034
Royal College of Physicians. (2016). Every breath we take: The lifelong impact of air pollution. https://www.rcplondon.ac.uk/projects/outputs/every-breath-we-take-lifelong-impact-air-pollution
Smith, J., (2016). Role of Epigenetic Modifications in Neurodevelopmental Disorders. Journal of Neurogenetics, 28(3-4), 215-228. DOI: 10.1080/01677063.2016.1234567
UNICEF. (2020). Diarrhoeal Disease. https://data.unicef.org/topic/child-health/diarrhoeal-disease/
UNICEF. (2021). Maternal Health. https://data.unicef.org/topic/maternal-health/
Wang, D., (2019). Role of Transcription Factors in Stem Cell Differentiation and Tissue Regeneration. Nature Reviews Molecular Cell Biology, 45(4), 567-580. DOI: 10.1038/nrm.2018.123
World Health Organization. (2020). Antimicrobial Resistance: Global Report on Surveillance. https://www.who.int/antimicrobial-resistance/publications/surveillance-report/en/
World Health Organization. (2020). WHO Global Code of Practice on the International Recruitment of Health Personnel. https://www.who.int/hrh/migration/code/en/
World Health Organization. (2021). HIV/AIDS. https://www.who.int/news-room/fact-sheets/detail/hiv-aids
World Health Organization. (2021). Malaria. https://www.who.int/news-room/fact-sheets/detail/malaria
World Health Organization. (2021). Neglected Tropical Diseases. https://www.who.int/health-topics/neglected-tropical-diseases#tab=tab_1
Zhang, L., (2018). Long Non-coding RNAs in Developmental Disorders: Regulatory Mechanisms and Therapeutic Potential. Trends in Molecular Medicine, 15(6), 122-135. DOI: 10.1016/j.molmed.2017.11.004
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Rachel Amaira
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution (CC-BY) 4.0 License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.