PREDICTORS OF ADHERENCE TO HIGHLY ACTIVE ANTIRETROVIRAL THERAPY (HAART) AMONG HIV PATIENTS ATTENDING SELECTED COMPREHENSIVE CARE CENTRES (CCC) IN KERICHO COUNTY
DOI:
https://doi.org/10.47604/jhmn.1191Keywords:
Highly Active Antiretroviral Therapy, HIV Patients, Care CentresAbstract
Purpose: The main objective of the study was to determine Predictors of adherence to Highly Active Antiretroviral Therapy among HIV patients attending selected comprehensive care centres in Kericho County. Specifically, this study sought to determine the socio-demographic and socio-economic factors that affect adherence HAART.
Methodology: A descriptive cross-sectional study was used. It involved 280 HIV patients (≥ 15 years) on HAART in three selected Comprehensive Care Centres in Kericho County. Data was collected from the patients using interviewer administered semi-structured questionnaires while Key informant interviews were held with healthcare providers involved in HIV care at the selected facilities. Viral load was used as a measure of adherence. This was done by retrospective review of the patient files. The three facilities where this study was done were picked using purposive sampling. systematic sampling was then utilized to attain the calculated sample size for each facility. Data was entered into Statistical Package for Social Sciences (SPSS) version 25.0 and analysis was done through descriptive and inferential statistics. Descriptive statistics; frequencies and percentages was used to summarize the data set. Inferential statistics was done using logistic regression analysis (Univariate and multivariate). The p-value was set at 0.05.Summary statistic of independent variables was presented using frequency tables, pie charts and bar graphs.
Findings: 76% of the respondents had optimal adherence while 24% had sub-optimal adherence. More females than males were on treatment. There was an insignificant difference in adherence between males and females. Only age (category 20-24 years) p=0.023 and expenditure on food(p=0.04) had significant association with adherence to HAART.
Unique contribution to theory, practice and policy: An understanding of these predictors will allow for targeted interventions to increase adherence to HAART and improve the health outcomes of PLHIV. Healthcare providers will be able to develop educational programmes and materials that target HIV patients at risk of sub-optimal adherence.
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References
2. AVERT. (2017). Global information and education on HIV and AIDS. HIV AND AIDS IN KENYA.
3. Ayalu, A. R., Sibhatu, B., Kebede, D. & Amare, D. (2013). Determinants of Adherence to Antiretroviral Therapy among HIV-Infected Patients in Africa. ." AIDS RESEARCH AND TREATMENT . Aiids Research and Treatment.
4. Bangsberg, D. R., Perry, S. Charlebois E. D., et al. (2001). Non-adherence to highly active antiretroviral therapy predicts progression to AIDS. pubmed.gov.
5. Berhe, N., Tegabu, D. & Alemayehu, M. (2013). Effect of nutritional factors on adherence to antiretroviral therapy among HIV-infected adults: a case control study in Northern Ethiopia. Infectitious diseases
6. Cairns, G. (2016). Very high levels of drug resistance seen in people experiencing first-line antiretroviral therapy failure in Kenya.
7. Fonsah, J.Y., Njamnshi, A.K., Kouanfack, C. (2017). Adherence to Antiretroviral Therapy (ART) in Yaounde´-Cameroon. Plos One, 11.
8. Heestermans, T., Browne, J.L., Aitken, S.C., Vervoort, S.C., KlipsteinGrobusch, K. (2016). . Determinants of adherence to antiretroviral therapy. BMJ Global health .
9. KAIS. (2012). Kenya AIDS Indicator Survey 2012. Nairobi.
10. Langebeek, N., Gisolf, E.H., Reiss, P. et al. (2014). Predictors and correlates of adherence to combination antiretroviral therapy (ART) for chronic HIV infection: a meta-analysis. BMC med.
11. Mavhandu-Mudzusi, A. H. & Fikadu, T. N. (2020). Magnitude of non-adherence to antiretroviral therapy and associated factors among adult people living with HIV/AIDS in Benishangul-Gumuz Regional State, Ethiopi. Peer journal.
12. Momanyi, Z.K., Karanja, S. & Mbakaya, C. (2017). Factors associated with the Prevalence of Non Adherence to Antiretroviral Therapy among HIV Positive Patients in Kibra Slums, Nairobi,Kenya.
13. Monjok, E., Andrea, S., Okokon, I., Osaro, M. & Essien, J. (2010). Adherence to antiretroviral therapy in Nigeria: an overview of research studies and implications for policy and practice.
14. Muya, G.P. & Hertzmark.E (2014). Predictors of Nonadherence to Antiretroviral Therapy among HIV-Infected Adults in Dar es Salaam, Tanzania. Journal of the International Association of Providers of AIDS care(JIAPAC).
15. National AIDS Control Council NACC and National AIDS and STI Control Program NASCOP, Ministry of Health (2018). Kenya HIV estimates report. Nairobi.
16. National AIDS and STI Control Program NASCOP, Ministry of Health. (2015). The Kenya HIV Testing and counseling services guidelines.
17. National AIDS and STI Control Program NASCOP, Ministry of Health. (2018). Ministry of Health, National AIDS & STI Control Program. Guidelines on Use of Antiretroviral Drugs for Treating and Preventing HIV Infection in Kenya 2018 Edition.
18. National AIDS and STI Control Program NASCOP, Ministry of Health. (2020). Preliminary KENPHIA 2018 Report. Nairobi.
19. Onywera, D. M., Seth, I., Auma, E., Were, K., Harrison, F.,Owiti, P.,Opollo, V., Jean-François, E., Mukui, I., Andrea, A. K. & Clement, Z. (2017). Surveillance of HIV-1 pol transmitted drug resistance in acutely and recently infected antiretroviral drug-naïve persons in rural western Kenya.
20. Sandeep, R., Mahapatra, B.,Subhashish, S., Raj, P., Srinivasan, V. M.& Bharat B. (2013). Adherence to Antiretroviral Therapy and Its Effect on Survival of HIV-Infected Individuals in Jharkhand, India.
21. Semvua, S. K., Orrell, C., Mmbaga, B. T.,Semvua, H. H., Bartlett, J. A. & Boulle, A. A. (2017). Predictors of non-adherence to antiretroviral therapy among HIV infected patients in northern Tanzania.
22. Siphokazi, P., Goon, D. T., Uchenna, B. O.& Yako, E. M. (2018). Antiretroviral Treatment Adherence Among Patients in Selected Health Facilities in East. Online Journal of Health and Allied Sciences.
23. Joint United Nations program on HIV/AIDS, UNAIDS. (2017). Global HIV & AIDS statistics "” 2018 fact sheet.
24. Wakibi, S. N., Nga'ng'a, Z. W. & Gabriel, G. M. (2010). Prevalence and Predictors of Non-adherence, and Incidence of Treatment Failure among Patients on Free Highly Active Antiretroviral Therapy in Nairobi, Kenya.
25. Ochieng, W., Kitawi, R. C., Nzomo, T. J., Mwatelah, R. S., Kimulwo, M. J.,Ochieng, D. J., Kinyua, J., Lagat, N., Onyango, O. K., Lwembe, M. R., Mkaya, M., Ogutu, B. R., Oloo, F. A.& Rashid, A. (2015). Correlates of Adherence and Treatment Failure Among Kenyan Patients on Long-term Highly Active Anti-Retroviral Therapy.
26. Weiser, S. D., Tuller, D. M., Frongillo, E.A., Senkungu, J., Mukiibi, N. & Bangsberg, D.R. (2010). Food Insecurity as a Barrier to Sustained Antiretroviral Therapy Adherence in Uganda. Plos one journal
27. Win, L. A., Puckpinyo, A. & Peltzer, K. (2017). Non-adherence to anti-retroviral therapy among HIV infected adults in Mon State of Myanmar.
28. Yang, Y., Luo, D., Xi, C., Huang, Z., Wang, M. & Shuiyuan, X. (2018). Medication adherence to antiretroviral therapy among newly treated people living with HIV.
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